Clomipramine hydrochloride( —— )

Catalog No. M12629 CAS No. 17321-77-6

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Datasheet

HNMR

HPLC

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Product Name

Clomipramine hydrochloride
Note

Research use only, not for human use.
Brief Description

Clomipramine HCl is a serotonin transporter (SERT).
Description

Clomipramine HCl is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
In Vitro

Western Blot Analysis Cell Line:Primary cortical neurons Concentration:1 and 5?μM Incubation Time:12, 24 and 48?hours Result:Enhanced the LC3-I conversion to LC3-II in a concentration-dependent manner at all analyzed time points.
In Vivo

Animal Model:C57BL/6?J mice (6 weeks of age and 22 to 25?g).Dosage:20?mg/kg Administration:Treated intraperitoneally for 21 days Result:Both LC3-II and p62 were significantly increased in the liver of Clomipramine treated mice compared to vehicle treated ones.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT| Sert (Sodium-dependent)| GSTP| Noradrenaline transporter (Sodium-dependent)
Research Area

Neurological Disease
Indication

——

CAS Number

17321-77-6
Formula Weight

351.31
Molecular Formula

C19H23ClN2·HCl
Purity

>98% (HPLC)
Solubility

Ethanol: 70 mg/mL (199.25 mM); Water: 70 mg/mL (199.25 mM); DMSO: 70 mg/mL (199.25 mM)
SMILES

Cl.CN(C)CCCN1C2=CC=CC=C2CCC2=C1C=C(Cl)C=C2
Chemical Name

——

1.Hastak K, et al. Y Res. 2010 Aug 26.

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