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Clomipramine hydrochloride

CAS No. 17321-77-6

Clomipramine hydrochloride( —— )

Catalog No. M12629 CAS No. 17321-77-6

Clomipramine HCl is a serotonin transporter (SERT).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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50MG 36 In Stock
100MG 45 In Stock
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Biological Information

  • Product Name
    Clomipramine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Clomipramine HCl is a serotonin transporter (SERT).
  • Description
    Clomipramine HCl is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
  • In Vitro
    Western Blot Analysis Cell Line:Primary cortical neurons Concentration:1 and 5?μM Incubation Time:12, 24 and 48?hours Result:Enhanced the LC3-I conversion to LC3-II in a concentration-dependent manner at all analyzed time points.
  • In Vivo
    Animal Model:C57BL/6?J mice (6 weeks of age and 22 to 25?g).Dosage:20?mg/kg Administration:Treated intraperitoneally for 21 days Result:Both LC3-II and p62 were significantly increased in the liver of Clomipramine treated mice compared to vehicle treated ones.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT| Sert (Sodium-dependent)| GSTP| Noradrenaline transporter (Sodium-dependent)
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    17321-77-6
  • Formula Weight
    351.31
  • Molecular Formula
    C19H23ClN2·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 70 mg/mL (199.25 mM); Water: 70 mg/mL (199.25 mM); DMSO: 70 mg/mL (199.25 mM)
  • SMILES
    Cl.CN(C)CCCN1C2=CC=CC=C2CCC2=C1C=C(Cl)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hastak K, et al. Y Res. 2010 Aug 26.
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